Thank you for contacting Plugable support! Sorry to hear about this issue. I’d be more than happy to assist you.
If you haven’t already done so, fully unplug the dock from all devices, power, and Thunderbolt 3 cable to the host computer. Reboot your computer and after logging back in wait about 30-60 seconds, then reconnect the power cable first, Thunderbolt 3 host cable next, and USB/other devices last. Sometimes a reset in this order can resolve this kind of issue.
If that hasn’t helped, please check to ensure the dock is still showing up as authenticated in the Thunderbolt software. If the dock were somehow to be no longer authenticated, it will cause all USB communication to cease. See here if unfamiliar with this process: http://plugable.com/tbt3auth
If the dock is showing up as authenticated (“connected”), then we’ll want to get a closer look at the system for what might be happening. We have a troubleshooting tool that helps us find out what is going on in situations like this. Please plug the dock with your devices attached to it into your computer, then go to this page and follow the instructions there:
When emailing us the diagnostics results, mention ticket “349624” in the subject line.
Please don’t hesitate to let us know of other questions.
Thanks again for contacting Plugable support and best wishes!
Senior Engineer | Product Owner