Every so often my mouse and keyboard hooked up through the USB-C triple display docking station do not work after boot up/resume and I need to unplug the power from the docking station to get them working again. They have never stopped working while I actively used it. I am using a 2016 TB Mac.
I have not been able to pinpoint the exact sequence of steps to make this happen. But last time it happened after I have been using the hub, then disconnect from the hub, then shut down my computer while off the hub then plug in the hub before turning the computer back on.