Thanks for posting. I would be happy to help with your docking station!
When I view your screenshot the various elements appear to be in focus, so based on your description I would suspect a scaling issue of some sorts causing the behavior. I wrote a little about scaling behavior here --> http://plugable.com/2015/06/04/the-sc…
This behavior is most likely not the result of the dock, but of Windows itself, and tends to affect those using a system with a very high resolution internal display (you don’t mention which laptop you have) in conjunction with lower-resolution external displays (you don’t mention which Samsung monitor you are using). I know you mentioned that you have tried various resolution settings, but a common workaround to subvert this behavior would be to set the resolution of the internal display of your laptop to match that of your external Samsung monitor connected to the dock (following Option Two in this guide --> http://www.tenforums.com/tutorials/49…), and in addition have Windows set the display scaling to 100% (following part 4 of this guide --> http://www.tenforums.com/tutorials/21…) for each display. This should prevent Windows from scaling the content on all the displays and I would expect the quality to improve.
If you make the changes I describe does that help?