Thank you for contacting Plugable support! Sorry to hear about this issue. I’d be more than happy to assist you.
We’ve got a troubleshooting FAQ step that may help with this mouse situation:
Problem: My wired (or wireless) mouse and/or keyboard are experiencing lag/latency (jumpy/jerky mouse pointer movement, missing key-presses, duplicate key-presses, etc) when connected to the dock.
Solution: Dell released a patch that changes a Windows Registry entry related to the Intel Management Engine that is not Dell exclusive which has resolved these issues for several of our customers using a range of different host systems from different manufacturers. We recommend to try installing this patch if you have some of the aforementioned issues:
Since your mouse may stop working entirely until a reboot, this may be a different kind of problem, but the aforementioned patch will be a good place to start.
If it doesn’t help, what make and model laptop and mouse do you have?
Please don’t hesitate to let us know of other questions.
Thanks again for contacting Plugable support and best wishes!
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