Hi Srinivas - Yes, but with limitations and only on some operating systems. On Windows 7 and perhaps others, you can make the USB display the primary. Its workable to run with only a USB display connected. However, your computer’s system BIOS does not have support for USB attached displays - so until there is an opportunity for device drivers to load in the OS, the display will be blank. So you’d at least have to keep a VGA monitor handy to plug in when you need to do something to the BIOS or at boot time.