Cannot open COM3

I am running Windows 7 and just installed a Plugable USB to RS-232 DB9 Serial Adapter with the latest driver 3.3.17.203. when I try and use it with Hyper Terminal or TeraTerm I get: "Another program is using the selected Telephony device. Try again after the other program completes." Or : "Cannot open COM3" The Device Manager shows: "Prolific USB-to-Serial Comm Port(COM3)" under ports. Why cant I use it?
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